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Tracking switched outcomes in clinical trials - Tracking switched outcomes in clinical trials

Outcome switching in clinical trials is a serious problem. Between October 2015 and January 2016, the COMPare team systematically checked every trial published in the top five medical journals, to see if they misreported their findings. We are now submitting the first set of findings from the projec

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Tracking switched outcomes in clinical trials - Tracking switched outcomes in clinical trials | compare-trials.org Reviews
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Outcome switching in clinical trials is a serious problem. Between October 2015 and January 2016, the COMPare team systematically checked every trial published in the top five medical journals, to see if they misreported their findings. We are now submitting the first set of findings from the projec
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Tracking switched outcomes in clinical trials - Tracking switched outcomes in clinical trials | compare-trials.org Reviews

https://compare-trials.org

Outcome switching in clinical trials is a serious problem. Between October 2015 and January 2016, the COMPare team systematically checked every trial published in the top five medical journals, to see if they misreported their findings. We are now submitting the first set of findings from the projec

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1

COMPare - Methods

http://compare-trials.org/methods

Tracking switched outcomes in clinical trials. The COMPare ( CEBM. Outcome Monitoring Project) team. Is monitoring clinical trials for switched outcomes. Through increased awareness of misreported outcomes, individual accountability, and feedback for specific journals, we hope to fix the ongoing problem of outcome switching. Why outcome switching matters. And on a clinical trial registry. However, in reality, pre-specified outcomes are often left unreported, while outcomes that were not pre-specified are...

2

COMPare - Raw data

http://compare-trials.org/results

Tracking switched outcomes in clinical trials. The table below shows every trial we assessed, with links to our full assessments and the letters we sent to journals. It also shows whether journals published our letters. How to cite us. Prior to publication of the first paper on COMPare, please cite this project as:. The COMPare Trials Project. Goldacre B, Drysdale H, Powell-Smith A, et al. www.COMPare-trials.org, 2016. The COMPare Trials Project.

3

COMPare - Speaking dates

http://compare-trials.org/speaking

Tracking switched outcomes in clinical trials. We’ve teamed up with Skeptics in the Pub to talk about COMPare at various meetups in 2016/2017. We’ll be talking about outcome switching in clinical trials, the story of COMPare, and what happened when we tried to correct the record on 58 misreported trials… Full dates below. 30/08/2016, 7.30pm. The Style and Winch, 72 Union Street, Maidstone ME14 1ED. 05/10/2016, 7.30pm. The Rose, 16 King Street, Maidenhead SL6 1EF. 18/10/2016, 7.30pm. 26/10/2016, 7.30pm.

4

COMPare - FAQ

http://compare-trials.org/faq

Tracking switched outcomes in clinical trials. How is COMPare funded? No specific funding has been sought for COMPare. The PI Ben Goldacre receives academic funding from the Laura and John Arnold Foundation. Don’t journals already check for outcome switching? Journals generally say that they do, but our findings – and those from previous work on the subject – show that they do not. Are you publishing on this? Where do you get the information on pre-specified outcomes? On one of your assessments, you scor...

5

COMPare - Changes to pre-specified outcomes must be declared and explained in the published trial report

http://compare-trials.org/blog

Tracking switched outcomes in clinical trials. Annals update protocol sharing requirements for trialists, after COMPare finds shortcomings. May 3, 2016. The COMPare Trials research project assessed 5 trials published in Annals of Internal Medicine for misreported outcomes – a well-documented and common source of bias. We found that all 5 trials published in Annals. Over the 6 week period misreported their prespecified outcomes, and so we sent a correction letter on each trial. April 29, 2016. Have refuse...

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Tutto sulle malattie renali. Tutto sulla dieta nelle malattie renali. In difesa del metodo. Outcome switching nei trial clinici. Domande e risposte sulla statistica. Una visione critica dell’evidenza. Arti perdute in matematica. Saggi di filosofia della statistica. Saggi di filosofia della probabilità. ETHICAL ROOTS OF POPPER EPISTEMOLOGY. Saggio di M. Artigas. Saggi di R. Nesse. Introduzione alla probabilità. Sistema internazionale unità di misura. Matematica e fisica controcorrente. TeX per OS X.

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Past Events

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What is a Skeptic? Here are the speakers you have missed:. The Idiot Brain: What Your Head Is Really Up To. Wednesday, August 3 2016 at 7:30PM. Eg import to Outlook or Google Calendar). What's the talk about? The hugely popular Guardian Brain Flapping. Science blogger, Dean Burnett. Comes to Oxford to talk about his new book: The Idiot Brain. It is a surprising, funny and mind-bending examination of how and why the brain sabotages our behaviour. Join the Facebook event and invite your friends:. For 6 wee...

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George Hrab and the Geologic Universe. Wed, 17 August 2016. The Geologic Podcast Episode #475. Waking up from a nap. Religious Moron of the Week. John Hagee and his bad math. Guilt from my phone. Greenland sharks, Somniosus microcephalus. PFA playing a LOT. Finland, Finland, Finland! Mentioned in the Show. Turku concert on facebook. Subscribe and information on subscription levels. Sign up for the mailing list: Write to Geo! A reminder that the portal to the Geologic Universe is at GeorgeHrab.com. Mentio...

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Teaching and Teacher Learning. ICLON, Leiden University. Post by Category : PHD. Boundary Crossing: for the Love of Research. June 29, 2016. Lately, I have been occupied with the concept of boundary crossing. If you have worked or lived abroad, what were your experiences? What things did you find helpful (or not)? Below are some of my experiences:. Be prepared for the idea. Make good agreements with your partner/family. Be sure you have an adequate amount of saving money before moving to another country&...

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Past Events

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Wednesday, February 1 2017 at 7:30PM. Eg import to Outlook or Google Calendar). What's the talk about? To See a World in a Grain of Sand. Wednesday, December 7 2016 at 7:30PM. Eg import to Outlook or Google Calendar). What's the talk about? Last Skeptics Talk of 2016. See you there! It wasn’t me: Why do humans often act against their own best interests? Wednesday, November 2 2016 at 7:30PM. Eg import to Outlook or Google Calendar). What's the talk about? How and why the infrastructure of science is broken.

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PhD Archives - Teaching and Teacher Learning

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Teaching and Teacher Learning. ICLON, Leiden University. Posts for Tag : PhD. A guide to scientific skepticism. April 13, 2016. Tim van der Zee. Don’t take my word for it, but being a scientist is about being a skeptic. About not being happy with simple answers to complex problems. About always asking more questions. About not believing something merely because it. Nor about reading a scientific study and believing its conclusions because, again, it all. C) go far beyond what evidence exists.”. There is ...

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Tim van der Zee - Teaching and Teacher Learning

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Teaching and Teacher Learning. ICLON, Leiden University. A guide to scientific skepticism. April 13, 2016. Tim van der Zee. Don’t take my word for it, but being a scientist is about being a skeptic. About not being happy with simple answers to complex problems. About always asking more questions. About not believing something merely because it. Nor about reading a scientific study and believing its conclusions because, again, it all. A) derive from no evidence whatsoever (adult learning theory),. There i...

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Tracking switched outcomes in clinical trials - Tracking switched outcomes in clinical trials

Tracking switched outcomes in clinical trials. Tracking switched outcomes in clinical trials. We compared each clinical trial report with its protocol or registry entry. Some trials reported their outcomes perfectly. For the others, we counted how many of the outcomes pre-specified in the protocol or registry were never reported. We also counted how many new outcomes were silently added. Here’s what we found. New outcomes silently added. On average, each trial reported just. Letters rejected by editor.

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