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CABOMETYX™: now approved for advanced RCC

CABOMETYX™ (cabozantinib) is approved in patients who have received prior anti-angiogenic therapy for advanced RCC.

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CABOMETYX™: now approved for advanced RCC | hcp.cabometyx.com Reviews
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CABOMETYX™ (cabozantinib) is approved in patients who have received prior anti-angiogenic therapy for advanced RCC.
<META>
KEYWORDS
1 CABOMETYX
2 cabozantinib
3 MOA
4 mechanism of action
5 targeted
6 TKI
7 renal cell carcinoma
8 rcc
9 efficacy
10 safety
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important safety information,full prescribing information,for patients,mechanism,clinical data,trial design,baseline characteristics,progression free survival,overall survival,objective response rate,safety,dosing,strengths,administration,adjustments
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CABOMETYX™: now approved for advanced RCC | hcp.cabometyx.com Reviews

https://hcp.cabometyx.com

CABOMETYX™ (cabozantinib) is approved in patients who have received prior anti-angiogenic therapy for advanced RCC.

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1

CABOMETYX™ (cabozantinib) dosing and administration

https://hcp.cabometyx.com/dose-adjustments

CABOMETYX™ (cabozantinib) dose adjustments due to adverse reactions. Management of severe or intolerable adverse reactions may require:. Withhold for Grade 3 or intolerable Grade 2 adverse reactions that cannot be adequately managed with a dose reduction or supportive care. Withhold CABOMETYX™ for NCI-CTCAE Grade 4 adverse reactions. Ie, return to baseline or resolution to Grade 1) of an adverse reaction, reduce the dose by 20 mg. Permanently discontinue CABOMETYX™ for any of the following:. Fistulas wer...

2

CABOMETYX™: METEOR Trial design and results

https://hcp.cabometyx.com/objective-response-rate

Objective response rate (ORR): secondary endpoint. CABOMETYX™ (cabozantinib) significantly improved ORR (17%) vs everolimus (3%). Confirmed per independent radiology review committee (IRRC). CABOMETYX™ is the only single agent to significantly improve PFS, OS, and ORR in advanced RCC after prior treatment. Next: Safety ». New England Journal of Medicine. Full publications in the Resources section. Gastrointestinal (GI) Perforations and Fistulas:. Fistulas were reported in 1.2% (including 0.6% ana...Diarr...

3

CABOMETYX™ (cabozantinib) resources

https://hcp.cabometyx.com/access-support

EASE services are tailored to fit the needs of patients. ET, Monday to Friday. EASE provides solutions to the potential hurdles your office and patients may encounter, with the following programs to help access CABOMETYX tablets. EASE Representatives can provide information and answer questions relating to coverage, specialty pharmacy shipments, and financial assistance options/eligibility.*. Your patients who experience insurance coverage decision delays don't have to wait to initiate therapy. Download ...

4

CABOMETYX™: now approved for advanced RCC

https://hcp.cabometyx.com/index.php

After prior therapy* for advanced renal cell carcinoma (RCC),. With the Power of 3. Significant improvement across 3 endpoints. CABOMETYX™ (cabozantinib) Prescribing Information. Exelixis, Inc., 2016. CABOMETYX™ (cabozantinib) is indicated for the treatment of advanced renal cell carcinoma (RCC) in patients who have received prior anti-angiogenic. Gastrointestinal (GI) Perforations and Fistulas:. Fistulas were reported in 1.2% (including 0.6% anal fistula) of CABOMETYX-treated patients and 0% of ...PPES ...

5

CABOMETYX™ (cabozantinib) dosing and administration

https://hcp.cabometyx.com/management

In the METEOR trial, withholds, reductions, and discontinuations were used to manage adverse reactions. Median duration of hold was 7.0 days for CABOMETYX™ (cabozantinib) and 9.0 days for everolimus. The most common adverse reactions that led to dose reduction with CABOMETYX™ were. Diarrhea, palmar-plantar erythrodysesthesia syndrome, fatigue, hypertension. The most frequent adverse reactions leading to permanent discontinuation in patients treated with CABOMETYX™ were. Data on file. Exelixis, Inc. Fistu...

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exelixis.com exelixis.com

Medicines | Exelixis

http://www.exelixis.com/cometriq

Since its founding, Exelixis has been committed to the discovery and development of new medicines with the potential to improve care and outcomes for people with cancer. To date, three medicines that were discovered by Exelixis researchers have progressed through clinical development and received regulatory approval. Please see Important Safety Information for CABOMETYX, including warnings for hemorrhage and gastrointestinal perforations and fistulas, by clicking here. And full Prescribing Information.

exelixis.net exelixis.net

Medicines | Exelixis

http://www.exelixis.net/cometriq

Since its founding, Exelixis has been committed to the discovery and development of new medicines with the potential to improve care and outcomes for people with cancer. To date, three medicines that were discovered by Exelixis researchers have progressed through clinical development and received regulatory approval. Please see Important Safety Information for CABOMETYX, including warnings for hemorrhage and gastrointestinal perforations and fistulas, by clicking here. And full Prescribing Information.

exelixis.org exelixis.org

Medicines | Exelixis

http://www.exelixis.org/cometriq

Since its founding, Exelixis has been committed to the discovery and development of new medicines with the potential to improve care and outcomes for people with cancer. To date, three medicines that were discovered by Exelixis researchers have progressed through clinical development and received regulatory approval. Please see Important Safety Information for CABOMETYX, including warnings for hemorrhage and gastrointestinal perforations and fistulas, by clicking here. And full Prescribing Information.

carbozantinib.com carbozantinib.com

Medicines | Exelixis

http://www.carbozantinib.com/cometriq

Since its founding, Exelixis has been committed to the discovery and development of new medicines with the potential to improve care and outcomes for people with cancer. To date, three medicines that were discovered by Exelixis researchers have progressed through clinical development and received regulatory approval. Please see Important Safety Information for CABOMETYX, including warnings for hemorrhage and gastrointestinal perforations and fistulas, by clicking here. And full Prescribing Information.

exelixis.com exelixis.com

About Us | Exelixis

http://www.exelixis.com/about

Exelixis, Inc., from the Greek word for evolution, is a biopharmaceutical company committed to developing and commercializing small molecule therapies with the potential to improve the treatment of cancer. For important safety information about CABOMETYX. Ipsen has an exclusive license to commercialize cabozantinib outside of the United States, Canada and Japan, and is pursuing European Union approval for the same indication. Exelixis was founded and incorporated in 1994 and we are based in South San Fra...

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CABOMETYX™: now approved for advanced RCC

After prior therapy* for advanced renal cell carcinoma (RCC),. With the Power of 3. Significant improvement across 3 endpoints. CABOMETYX™ (cabozantinib) Prescribing Information. Exelixis, Inc., 2016. CABOMETYX™ (cabozantinib) is indicated for the treatment of advanced renal cell carcinoma (RCC) in patients who have received prior anti-angiogenic. Gastrointestinal (GI) Perforations and Fistulas:. Fistulas were reported in 1.2% (including 0.6% anal fistula) of CABOMETYX-treated patients and 0% of ...PPES ...

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