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Filling the groove of BCL-2 | amphoteros
https://amphoteros.com/2015/05/15/filling-the-groove-of-bcl-2
Forcing molecules to behave. Skip to primary content. Filling the groove of BCL-2. May 15, 2015. The impressive recent traction received by Abbvie’s Venetoclax is the subject of today’s post. Dr. G. Poda of OICR brought this molecule to my attention. Venetoclax constitutes a notable addition to the growing list of small molecule inhibitors that target protein-protein interactions. The compound just got the breakthrough therapy designation from the FDA, which speeds up the regulatory r...Link to the book ...
orgprepdaily.wordpress.com
Pleasures of Process Development | Org Prep Daily
https://orgprepdaily.wordpress.com/2014/11/06/pleasures-of-process-development
November 6, 2014. Pleasures of Process Development. Filed under: industry life. 8212; milkshake @ 8:32 pm. A reflux in 12 molar HCl. Carefully watched for a frothing,. Painstakingly drained from the reactor,. To strip down and scrub off that gross thing. My bosses, I tried please believe me,. I’m doing my best as you insist,. I’m ashamed of the material I burned through,. I’m ashamed of the deadlines we missed. But if you could just see the beauty,. These things I could never describe,. I have a protecti...
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How to leave a strong impression | Org Prep Daily
https://orgprepdaily.wordpress.com/2015/03/19/how-to-leave-a-strong-impression-as-intern
March 19, 2015. How to leave a strong impression. Filed under: lab destruction. 8212; milkshake @ 9:14 pm. In those days, the literature search used to be done with printed indexes of Chemical Abstracts. It was like slogging away through a supermarket shelf filled with phone books; I spent three weeks doing this. For a moment, it wasn’t clear who was going to suffer the heart attack first but eventually the shouting subsided, I got my face wiped clean with alcohol swabs and was ready to set up the ...
orgprepdaily.wordpress.com
bug report | Org Prep Daily
https://orgprepdaily.wordpress.com/report-a-problem
WordPress keeps improving the code behind the theme used in Org Prep Daily and the upgrades happen without warning. The old tiresome bugs (around which I found a way already) get swapped for fresh and exciting new ones. And suddenly pictures get corrupted at random or would not load at all, and for some reason the ones affected most often are the gif files of chemical structures generated from ChemDraw. Leave a Comment ». Feed for comments on this post. Leave a Reply Cancel reply. Enter your comment here.
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July | 2015 | Org Prep Daily
https://orgprepdaily.wordpress.com/2015/07
July 31, 2015. The End of Affair. Filed under: industry life. 8212; milkshake @ 12:43 pm. It lasted twelve months – longer than I could have hoped. I will always remember our time together: The stunning saffron, cinnamon and maroon colors of your intermediates, the lustrous shimmering of microcrystalline flakes when you precipitated; I held you in my hands so many times. Your central atom – a noble metal from the platinum group – will stay in my heart and bones forever. About Org Prep Daily.
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Org Prep Daily | synthetic procedures I tried and liked | Page 2
https://orgprepdaily.wordpress.com/page/2
November 6, 2014. Pleasures of Process Development. Filed under: industry life. 8212; milkshake @ 8:32 pm. A reflux in 12 molar HCl. Carefully watched for a frothing,. Painstakingly drained from the reactor,. To strip down and scrub off that gross thing. My bosses, I tried please believe me,. I’m doing my best as you insist,. I’m ashamed of the material I burned through,. I’m ashamed of the deadlines we missed. But if you could just see the beauty,. These things I could never describe,. July 4, 2014.
orgprepdaily.wordpress.com
The End of Affair | Org Prep Daily
https://orgprepdaily.wordpress.com/2015/07/31/the-end-of-affair
July 31, 2015. The End of Affair. Filed under: industry life. 8212; milkshake @ 12:43 pm. It lasted twelve months – longer than I could have hoped. I will always remember our time together: The stunning saffron, cinnamon and maroon colors of your intermediates, the lustrous shimmering of microcrystalline flakes when you precipitated; I held you in my hands so many times. Your central atom – a noble metal from the platinum group – will stay in my heart and bones forever. 1 Comment ». About Org Prep Daily.
orgprepdaily.wordpress.com
June | 2015 | Org Prep Daily
https://orgprepdaily.wordpress.com/2015/06
June 10, 2015. The power of blunder – based optimization. Filed under: industry life. 8212; milkshake @ 8:46 pm. I have been trying to optimize a difficult reaction; I thought a presence of zinc chloride might help so I gave this a try and there was an improvement: The results were getting better, week after week. About Org Prep Daily. Blog at WordPress.com. Follow “Org Prep Daily”. Get every new post delivered to your Inbox. Join 169 other followers. Build a website with WordPress.com.
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chemistry resources | Org Prep Daily
https://orgprepdaily.wordpress.com/chemistry-texts
Http:/ www.nmrs.io/. Http:/ stoltz.caltech.edu/theses.html. Http:/ www.scripps.edu/chem/baran/html/meetingschedule.html. Http:/ www.f.u-tokyo.ac.jp/ fukuyama/gmproblems.htm. Http:/ www.orgsyn.org/. Http:/ cssp.chemspider.com/Browse.aspx. Http:/ www.organic-chemistry.org/. Large pdf files – many MB each – the download takes patience). And now back to work –. People are watching you. Leave a Comment ». Feed for comments on this post. Leave a Reply Cancel reply. Enter your comment here. About Org Prep Daily.
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March | 2015 | Org Prep Daily
https://orgprepdaily.wordpress.com/2015/03
March 19, 2015. How to leave a strong impression. Filed under: lab destruction. 8212; milkshake @ 9:14 pm. In those days, the literature search used to be done with printed indexes of Chemical Abstracts. It was like slogging away through a supermarket shelf filled with phone books; I spent three weeks doing this. For a moment, it wasn’t clear who was going to suffer the heart attack first but eventually the shouting subsided, I got my face wiped clean with alcohol swabs and was ready to set up the ...