molecularinstruments.org

Molecular Instruments

Multiplexed in situ hybridization. Is an academic resource dedicated to the development and support of programmable molecular technologies for reading out and regulating cell state. We currently support multiplexed in situ hybridization. Using HCR, enabling simultaneous mapping of up to five target mRNAs within intact biological samples, including whole-mount vertebrate embryos. Researchers can order first-generation RNA HCR kits. Or next-generation DNA HCR kits. Mdash; The Molecular Instruments Team.

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Molecular Instruments | molecularinstruments.org Reviews

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Multiplexed in situ hybridization. Is an academic resource dedicated to the development and support of programmable molecular technologies for reading out and regulating cell state. We currently support multiplexed in situ hybridization. Using HCR, enabling simultaneous mapping of up to five target mRNAs within intact biological samples, including whole-mount vertebrate embryos. Researchers can order first-generation RNA HCR kits. Or next-generation DNA HCR kits. Mdash; The Molecular Instruments Team.

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Molecular Instruments | molecularinstruments.org Reviews

https://molecularinstruments.org

Multiplexed in situ hybridization. Is an academic resource dedicated to the development and support of programmable molecular technologies for reading out and regulating cell state. We currently support multiplexed in situ hybridization. Using HCR, enabling simultaneous mapping of up to five target mRNAs within intact biological samples, including whole-mount vertebrate embryos. Researchers can order first-generation RNA HCR kits. Or next-generation DNA HCR kits. Mdash; The Molecular Instruments Team.

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molecularinstruments.org

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Molecular Instruments

http://www.molecularinstruments.org/info/references

Multiplexed in situ hybridization. Programmable in situ amplification for multiplexed imaging of mRNA expression. Harry M.T. Choi, Joann Y. Chang, Le A. Trinh, Jennifer E. Padilla, Scott E. Fraser, and Niles A. Pierce. 28:1208 1212, 2010. Next-generation in situ hybridization chain reaction: higher gain, lower cost, greater durability. Harry M.T. Choi, Victor A. Beck, and Niles A. Pierce.

2

Molecular Instruments

http://www.molecularinstruments.org/info/faq

Multiplexed in situ hybridization. What are the differences between Validated Kits and Custom Kits? Kit has been validated in situ by the Molecular Instruments Team. Serves as positive control. Orders ship within approximately 2 business days. Probe set synthesized from scratch. Orders ship within approximately 10 business days. Kits selected from the library will ship within approximately 2 business days. How many probes do you recommend per probe set? Can I mix and match HCR amplifiers and Alexa Fluors?

3

Molecular Instruments

http://www.molecularinstruments.org/order/dnakits

Multiplexed in situ hybridization. Order DNA HCR Kits. Kit has been validated in situ by the Molecular Instruments Team. Serves as positive control. Orders ship within approximately 2 business days. Probe set synthesized from scratch. Orders ship within approximately 10 business days. Kits selected from the library will ship within approximately 2 business days. Select the number of probes in the probe set. Validated kits: number of probes is fixed. 20 pmole for zebrafish. 40 pmole for chick. 240 mL for ...

4

Molecular Instruments

http://www.molecularinstruments.org/info/hybridization

Multiplexed in situ hybridization. Order DNA HCR Kits. Multiplexed in situ hybridization using HCR. In situ hybridization methods enable the mapping of mRNA expression within intact biological samples. Multiplexed in situ amplification based on the mechanism of hybridization chain reaction (HCR) enables simultaneous mapping of up to five target mRNAs in diverse organisms and imaging contexts, including whole-mount vertebrate embryos. How HCR in situ amplification works.

5

Molecular Instruments

http://www.molecularinstruments.org/info/patents

Multiplexed in situ hybridization. Inventors: Robert Dirks, Niles Pierce. Patent: US 7,632,641 B2, Issued: 12/15/2009. Patent: EPO 1730161, Issued: 9/8/2010. Patent: US 8,105,778 B2, Issued: 1/31/2012. Hybridization Chain Reaction: Amplification for In Situ Imaging. Inventors: Niles Pierce, Robert Dirks, Scott Fraser. Patent: US 7,727,721 B2, Issued: 6/1/2010. Patent: US 8,124,751 B2, Issued: 2/28/2012.

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piercelab.caltech.edu

The Pierce Lab - Caltech - Resources

http://piercelab.caltech.edu/resources

California Institute of Technology. Is a growing software suite for the analysis and design of nucleic acid molecules, devices, and systems. Is a non-profit academic resource dedicated to the development and support of programmable molecular instruments for reading out and regulating the state of endogenous biological circuitry within intact organisms. 2015 • Contact.

piercelab.caltech.edu

The Pierce Lab - Caltech - People

http://piercelab.caltech.edu/people

California Institute of Technology. Prof Niles A. Pierce. Division of Biology &amp Biological Engineering. Division of Engineering &amp Applied Science. Director, Molecular Instruments. Division of Biology &amp Biological Engineering. Division of Biology &amp Biological Engineering. Division of Biology &amp Biological Engineering. Division of Biology &amp Biological Engineering. Biochemistry and Molecular Biophysics. Division of Biology &amp Biological Engineering. Postdoctoral Scholar, University of Bonn.

molecular-programming.org

MPP: Resources

http://molecular-programming.org/resources.html

An Expedition in Computing. Funded by the National Science Foundation. An Expedition in Computing. Funded by the National Science Foundation. Optical imaging of individual biomolecules in densely packed clusters. Jul 4, 2016. Single-molecule RNA detection at depth via hybridization chain reaction and tissue hydrogel embedding and clearing. Jun 25, 2016. Multiplexed miRNA northern blots via hybridization chain reaction. Jun 8, 2016. May 19, 2016. May 6, 2016. Visit the Molecular Instruments home page.

beckmaninstitute.caltech.edu

Beckman Institute | Caltech

http://beckmaninstitute.caltech.edu/~bi/announcements.shtml

Arnold and Mabel Beckman Foundation. Campus Mass Spectrometry Resources. Beckman Institute Seminar Series. The Beckman Institute Seminar Series provides the Caltech community greater awareness of opportunities. One of our Resource Centers, Facilities or Pilot Projects will sponsor a presentation and open house to highlight its capabilities and instrumentation, especially new acquisitions and developments. The next seminar will be scheduled in early fall 2016. The museum is also open by appointment to ind...

beckmaninstitute.caltech.edu

Beckman Institute | Caltech

http://beckmaninstitute.caltech.edu/announcements.shtml

Arnold and Mabel Beckman Foundation. Campus Mass Spectrometry Resources. Beckman Institute Seminar Series. The Beckman Institute Seminar Series provides the Caltech community greater awareness of opportunities. One of our Resource Centers, Facilities or Pilot Projects will sponsor a presentation and open house to highlight its capabilities and instrumentation, especially new acquisitions and developments. The next seminar will be scheduled in early fall 2016. The museum is also open by appointment to ind...

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molecularinstruments.org

Molecular Instruments

Multiplexed in situ hybridization. Is an academic resource dedicated to the development and support of programmable molecular technologies for reading out and regulating cell state. We currently support multiplexed in situ hybridization. Using HCR, enabling simultaneous mapping of up to five target mRNAs within intact biological samples, including whole-mount vertebrate embryos. Researchers can order first-generation RNA HCR kits. Or next-generation DNA HCR kits. Mdash; The Molecular Instruments Team.

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