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Receptome, LLC - the next generation of immunity

Adjuvant for DNA, RNA, and viral vectored vaccines. Dendritic Cell Vaccines for Cancer. Generating strong immunity against infections and cancer. Receptome uses LMP1, a naturally clustering membrane protein, to fuse with receptor signaling domains. This results in constitutively activated receptors that no longer need a ligand to function. 2015 Receptome, LLC.

http://www.receptome.com/

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Receptome, LLC - the next generation of immunity | receptome.com Reviews
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Adjuvant for DNA, RNA, and viral vectored vaccines. Dendritic Cell Vaccines for Cancer. Generating strong immunity against infections and cancer. Receptome uses LMP1, a naturally clustering membrane protein, to fuse with receptor signaling domains. This results in constitutively activated receptors that no longer need a ligand to function. 2015 Receptome, LLC.
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Receptome, LLC - the next generation of immunity | receptome.com Reviews

https://receptome.com

Adjuvant for DNA, RNA, and viral vectored vaccines. Dendritic Cell Vaccines for Cancer. Generating strong immunity against infections and cancer. Receptome uses LMP1, a naturally clustering membrane protein, to fuse with receptor signaling domains. This results in constitutively activated receptors that no longer need a ligand to function. 2015 Receptome, LLC.

INTERNAL PAGES

receptome.com receptome.com
1

Receptome, LLC - the next generation of immunity

http://www.receptome.com/Management.html

The Company is directed by Richard S. Kornbluth, MD, PhD, Chief Executive Officer and Chief Scientific Officer. Dr. Kornbluth invented Receptome's technology when he was an Associate Professor of Medicine at the University of California San Diego. He is also the founder of another UCSD spinout, Multimeric Biotherapeutics, Inc., a separately incorporated San Diego company that develops highly active forms of the TNF SuperFamily ligands. Activated Receptor Cassette - "ARC". 2016 Receptome, LLC.

2

Receptome, LLC - the next generation of immunity

http://www.receptome.com/Adjuvant.html

Adjuvant for DNA, RNA, and Viral Vectored Vaccines. Since LMP1 is an cell membrane protein, it must be delivered to cells as a nucleic acid. This can either be done using DNA or RNA vaccines or viral vectored vaccines such as adenovirus (Ad). In other studies, DNA vaccination by intramuscular plasmid injection protected mice from melanoma metastases. Further studies on cancer are being conducted. Activated Receptor Cassette - "ARC". 2016 Receptome, LLC.

3

Receptome, LLC - the next generation of immunity

http://www.receptome.com/DC%20cancer%20vaccines.html

LMP1-Enhanced Dendritic Cell Vaccines for Cancer. Since LMP1 is a viral mimic of a constitutively activated CD40 receptor, studies were performed to detemine if LMP1 activated DCs. Using LMP1 delivered as mRNA, DNA, or by viral vectors, DCs were stimulated to express activation markers (CD80, CD86, CD54, CD83, and CCR7), secrete cytokines, and act as APCs to generate CD8 T cells in vitro. Data coutesy of Dr. Geoffrey Stone, University of Miami. Patent US8932575 B2. Activated Receptor Cassette - "ARC".

4

Receptome, LLC - the next generation of immunity

http://www.receptome.com/index.html

Generating strong immunity against infections and cancer. In addition, the N-terminal domain of LMP1 consists of 6 transmembrane domains and leads to aggregation of C-terminally located amino acids. This aggregation can be used to make constitutively activated forms of a number of important receptors. For example, the LMP-induced aggregation of IPS-1 leads to activation of the same pathway as STING. LMP-IPS-1 has significant potential as a vaccine adjuvant and cancer immunotherapy agent.

5

Receptome, LLC - the next generation of immunity

http://www.receptome.com/About.html

About Receptome, LLC. Activated Receptor Cassette - "ARC". Receptome fuses the N-terminus of LMP1, a naturally clustering membrane protein, with receptor signaling domains. The ensuing clustering of the receptor domains allows for constitutive activation of selected receptors without requiring an extracellular ligand or agonistic antibody. The ARC-receptor coding sequence can be included in viral vectors or used as part of an RNA or DNA vaccine. 2015 Receptome, LLC.

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Receptome, LLC - the next generation of immunity

Adjuvant for DNA, RNA, and viral vectored vaccines. Dendritic Cell Vaccines for Cancer. Generating strong immunity against infections and cancer. Receptome uses LMP1, a naturally clustering membrane protein, to fuse with receptor signaling domains. This results in constitutively activated receptors that no longer need a ligand to function. 2015 Receptome, LLC.

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HPMR - Human Plasma Membrane Receptome

Receptome genes have been matched with their ligands for surveying DNA microarray datasets. Their own microarray data to perform online genome-wide online searches for paracrine/autocrine signaling systems. Survey of transcriptomes based on liganded receptome allows the discovery of paracrine/autocrine signaling for known ligand-receptor pairs in previously uncharacterized tissues or developmental stages. Sci STKE, Vol. 2003, Issue 187, pp. re9, 17 June 2003. Full text reprint available upon REQUEST.

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HPMR - Human Plasma Membrane Receptome

Receptome genes have been matched with their ligands for surveying DNA microarray datasets. Their own microarray data to perform online genome-wide online searches for paracrine/autocrine signaling systems. Survey of transcriptomes based on liganded receptome allows the discovery of paracrine/autocrine signaling for known ligand-receptor pairs in previously uncharacterized tissues or developmental stages. Sci STKE, Vol. 2003, Issue 187, pp. re9, 17 June 2003. Full text reprint available upon REQUEST.

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