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Target Heart Biotech S.r.l.

Target Heart Biotec discovered the muscle-specific protein Melusin, with a key function in triggering increased muscular power (compensatory cardiac hypertrophy) when the heart is subjected to an exceptional work load.

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CONTACTS AT THBIOTEC.COM

TARGET HEART BIOTEC SRL

Via ●●●●s, 5

Coller●●●●●●iacosa , 10010

IT

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Guido Tarone

Guido Tarone

Via ●●●●s, 5

Coller●●●●●●iacosa , 10010

IT

39 01●●●●●38874
39 01●●●●●38791
gu●●●●●●●●●●@unito.it

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PAGE TITLE
Target Heart Biotech S.r.l. | thbiotec.com Reviews
<META>
DESCRIPTION
Target Heart Biotec discovered the muscle-specific protein Melusin, with a key function in triggering increased muscular power (compensatory cardiac hypertrophy) when the heart is subjected to an exceptional work load.
<META>
KEYWORDS
1 Eporgen
2 Target Heart Biotec
3 portfolio
4 heart
5 heart disease
6 melusin
7 Guido Tarone
8 Giuseppe Lembo
9 Mara Brancaccio
10 Luciano Stabile
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about us,organizational structure,business development,technology and products,melusin,recombinant human melusin,proof of concept,patents,press room,literature,factsheet,designed by
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Target Heart Biotech S.r.l. | thbiotec.com Reviews

https://thbiotec.com

Target Heart Biotec discovered the muscle-specific protein Melusin, with a key function in triggering increased muscular power (compensatory cardiac hypertrophy) when the heart is subjected to an exceptional work load.

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1

Target Heart Biotech - Melusin structure and expression

http://www.thbiotec.com/melusin.asp

Melusin structure and expression. Click on the figure to enlarge. Is a protein selectively expressed in skeletal muscle and heart, and binding to the beta1 integrin cytoplasmic domain ( Brancaccio et al., 1999. Primary amino acidic sequence of melusin ( Fig. 2. Revealed the presence of two cysteine/histidine rich domains capable of binding Zn2 known as CHORD domains at the N-terminal portion of the protein (red globules). However, when heart is exposed to conditions of chronic pressure overload, such as ...

2

Target Heart Biotech Literature

http://www.thbiotec.com/patents.asp

Target Heart Biotech s patents:. Melusin, a muscle specific protein, as a drug target for prevention and treatment of heart failure. Filed by the University of Turin, with priority date in December 2002; Target Heart has the global, exclusive rights to this patent. The patent has been granted in the US, Europe and Canada; EP15753534B1; USA 7,531,714; CA 2740237). Recombinant melusin fusion protein as pharmacological agent in the treatment of heart pathologies and compositions thereof.

3

About Target Heart Biotech S.r.l.

http://www.thbiotec.com/about.asp

About Target Heart Biotec. TH was founded in June 2005 by Prof. Guido Tarone, Prof. Giuseppe Lembo and Prof. Mara Brancaccio. It has been incubated by Eporgen Venture in the Silvano Fumero Bioindustry Park, close to Ivrea in the Piedmont region of Italy, and received so far investments of about 1.000.000. TH has active collaborations with various italian academic institutions including:. The Molecular Biotechnology Centre at the University of Turin. Target Heart Biotech S.r.l.

4

Target Heart Biotech - Melusin proof of concept studies in animal models

http://www.thbiotec.com/melusin_proof.asp

Proof of concept studies in animal models. R-h melusin treatment in a mouse model of pressure overload induced heart failure protects from left ventricle dilation and loss of contractility. Target Heart Biotech S.r.l. BioIndustry Park Silvano Fumero. Via Ribes 5, 10010 Colleretto Giacosa (TO).

5

Target Heart Biotech Recombinant human melusin

http://www.thbiotec.com/melusin_recombinanthuman.asp

A recombinant human melusin construct was designed and produced internally in a very small scale for preclinical studies. Rationale of the construct:. MBP (maltose binding protein) was included in the construct to improve the stability and the purification yield. Target Heart Biotech S.r.l. BioIndustry Park Silvano Fumero. Via Ribes 5, 10010 Colleretto Giacosa (TO).

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eporgen.com eporgen.com

Target Heart Biotech

http://www.eporgen.com/aziende/targetheart.asp

Originated from the University of Torino; established in 2005, it operates in the cardiovascular field. Two patents filed in 2002 and 2010. Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload , De Acetis et al. (2005), Circulation Research, 96. Link: http:/ www.ncbi.nlm.nih.gov/pubmed/15860758. 2003) Nature Medicine, 9. Link: http:/ www.ncbi.nlm.nih.gov/pubmed/12496958. 2007) Eur. J. Heart Failure, 9. Pharmacokinetic tests (pre-clinical model in a...

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Target Heart Biotech S.r.l.

Target Heart Biotec (TH) is a spin-off from the University of Turin, Italy. It is a virtual company that operates in the cardiovascular field and belongs to the portfolio of Eporgen Venture. TH discovered the muscle-specific protein melusin. R-h melusin) has been manufactured, characterised and its therapeutic activity has been demonstrated in a pressure overload mouse model. TH is now seeking partnerships. To develop r-h melusin towards its various therapeutic applications.

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